Atletico Madrid must defeat the opposition at the Metropolitano in order to maintain their hopes of qualifying for the Champions League. For Diego Simeone's club, which has proven time and time again to have the tenacity to come back in crucial knockout games, it is a familiar struggle. But this time, the biggest challenge of all is probably Real Madrid, a team that thrives in these situations more than any other.

Atletico, a team that thrives on hardship and has established a reputation for resiliency, is on one side. The team that has made comebacks a regular occurrence and has an almost legendary supremacy in this event is Real Madrid, the masters of the biggest stage. Madrid's deadliest rivalry is about to enter a new and exciting chapter as the battle lines are formed and the stakes are high.

Simeone is faced with a tactical conundrum, and the growing list of absences is more of a problem than strategy. Lenglet and De Paul's availability is still uncertain, and Koke is still out. Against a team that thrives on punishing mistakes, the Argentine coach must reconstruct his team with no room for error, finding a delicate balance between full-on attack and defensive prudence.

Real Madrid is the side that has perfected the art of securing a Champions League knockout match. Los Blancos have advanced in 21 of their last 22 knockout rounds after grabbing the lead in the first leg, so the numbers speak for themselves. Even more intimidating is the fact that in their last nine two-legged matches, they have never given up an advantage. Unmatched in his ability to set the pace, Carlo Ancelotti is able to gradually undermine an opponent's confidence while protecting his team's future by knowing just when to apply pressure and when to let it go.

In the Champions League, Real Madrid and Atletico de Madrid have produced innumerable memorable moments. Their most recent matchup is sure to be another thrilling chapter in this legendary rivalry. The second leg of their round-of-16 matchup is expected to be exciting because everything is on the line.

For Atletico, it's a struggle for survival—an opportunity to change the course of history and go past the mental obstacle that has prevented them from defeating Real Madrid on the biggest stages in Europe. With the poise and experience that have characterized their supremacy in this competition, Los Blancos are adept at closing the deal once they take the lead. While one team battles the odds, the other team thrives on them. Everything is in place for a historic Madrid derby.

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